NFL Lines Week 11: Spreads, Storylines & Betting Notes for Every NFL Week 11 Game

NFL Week 11 could have the best slate of games scheduled we've seen all season, featuring two potential Game of the Year matchups in the NFC: the Seahawks vs. Rams and the Lions vs. Eagles. The struggling Commanders also take on the Dolphins in the NFL's first-ever game in Madrid, Spain.

Here are the NFL Week 11 lines, along with the spreads, over/unders, top storylines, and a key piece of betting info for each game on the docket.

NFL Lines Week 11 At a Glance

NFL Betting Lines Week 11: Spreads, Storylines & Betting Tips

The NFL has really spoiled us with this Week 11 slate, which should be hands down the best Sunday of the regular season, with so many marquee games and important conference matchups that will shape the playoff races and path to Super Bowl LX.

Granted, we aren't exactly starting the week in grand fashion as the Jets are a big underdog against the Patriots on Thursday Night Football. But crazier things have happened with division upsets in those spots.

Sunday's action gets started with the first NFL regular-season game in Madrid, Spain, as the Dolphins take on the Commanders. Miami is coming off a huge upset against the Bills and could go on a winning streak, while the Commanders continue to fade without Jayden Daniels.

In the 1:00 PM window, the marquee matchup is Tampa Bay at Buffalo in a battle of 6-3 teams who both lost last week. We'll see if they can rebound and come back to win the divisions they've been winning year after year. But don't sleep on the Bengals vs. Steelers rematch of the Unc Bowl from a few weeks ago, as Aaron Rodgers and Joe Flacco put on a show in that one as the two oldest quarterbacks in the NFL.

In the late-afternoon window, we have some heavyweight division battles that we've yet to see this year. The Seahawks and Rams are two of the hottest teams in football, so that game could go a long way in determining who wins the NFC West and maybe the NFC overall for the No. 1 seed. It can also catapult Sam Darnold or Matthew Stafford to the top of the MVP race. Then we also have the Kansas City Chiefs in Denver in a battle that could determine if we have a new champion in the AFC West for the first time since 2015 as the Chiefs (5-4) desperately need a win coming off their bye week. The Broncos (8-2) are tied for the best record in the NFL, but they looked bad in last week's 10-7 win over the Raiders. It's a huge opportunity for them to prove themselves against the gold standard in the AFC.

On Sunday night, we finally get to see the Detroit Lions take on the Philadelphia Eagles. They have been the two best teams in the NFC since 2024, but this is the first time they will match up in that span. Dan Campbell did a great job calling plays for the offense last week while the Eagles squeezed out a 10-7 win in Green Bay to stay on top of the NFC with a 7-2 record. This one is significant for playoff seeding in the NFC and also for Detroit's reputation, as it goes outdoors to beat a major contender.

After that epic Sunday, things will calm down a bit on Monday night as the Dallas Cowboys are in Las Vegas to take on the Raiders in another potential shootout—if the good version of Geno Smith shows up for that one.

That said, let's break down the NFL Week 11 lines with the latest odds and expert betting info for each game. New users can also sign up at the best NFL betting sites for Week 11 to snag several sportsbook bonuses.

Thursday | 8:15 PM ET | New York Jets vs. New England Patriots

• Spread: NE -12.5
• Total: 43.5
• Moneyline: Jets (+610); Patriots (-900)

🎯 Betting Tip: Underdogs of at least 7 points are 5-0 ATS in Thursday night division games this season.

Sunday | 9:30 AM ET | Washington Commanders vs. Miami Dolphins

• Spread: MIA -2.5
• Total: 47.5
• Moneyline: Commanders (+132); Dolphins (-156)

🎯 Betting Tip: Miami's last four games have been decided by at least 17 points, and Washington's offense is the only that has yet to have the ball in a one-score game in the fourth quarter this season.

Sunday | 1:00 PM ET | Chicago Bears vs. Minnesota Vikings

• Spread: MIN -3
• Total: 47.5
• Moneyline: Bears (+140); Vikings (-166)

🎯 Betting Tip: Since 2022, Minnesota's Kevin O'Connell is is 9-10-1 ATS in division games.

Sunday | 1:00 PM ET | Green Bay Packers vs. New York Giants

• Spread: GB -7
• Total: 43.5
• Moneyline: Packers (-360); Giants (+285)

🎯 Betting Tip: The 2025 Packers are 0-5 ATS and 2-2-1 SU as a favorite of at least 6.5 points.

Sunday | 1:00 PM ET | Carolina Panthers vs. Atlanta Falcons

• Spread: ATL -3.5
• Total: 42.5
• Moneyline: Panthers (+154); Falcons (-184)

🎯 Betting Tip: Carolina quarterback Bryce Young is 9-13 at game-winning drive opportunities while Michael Penix Jr. is 0-6 in his career.

Sunday | 1:00 PM ET | Los Angeles Chargers vs. Jacksonville Jaguars

• Spread: LAC -2.5
• Total: 43.5
• Moneyline: Chargers (-152); Jaguars (+128)

🎯 Betting Tip: The Chargers (+0.3) and Jaguars (-0.9) have not outperformed the spread by more than an average of 1 point in either direction this season.

Sunday | 1:00 PM ET | Cincinnati Bengals vs. Pittsburgh Steelers

• Spread: PIT -5.5
• Total: 49.5
• Moneyline: Bengals (+190); Steelers (-230)

🎯 Betting Tip: Joe Flacco is now 13-13 against Mike Tomlin's Steelers in his career with a win earlier this season.

Sunday | 1:00 PM ET | Tampa Bay Buccaneers vs. Buffalo Bills

• Spread: BUF -5.5
• Total: 47.5
• Moneyline: Buccaneers (+220); Bills (-270)

🎯 Betting Tip: The under is 8-4 in Buffalo games following a loss since 2023.

Sunday | 1:00 PM ET | Houston Texans vs. Tennessee Titans

• Spread: HOU -7
• Total: 38.5
• Moneyline: Texans (-355); Titans (+285)

🎯 Betting Tip: The Titans have already lost 26-0 to Houston this year and have the worst performance against the spread (-6.4 points on average) of all 2025 teams.

Sunday | 4:05 PM ET | Seattle Seahawks vs. Los Angeles Rams

• Spread: LAR -3
• Total: 48.5
• Moneyline: Seahawks (+138); Rams (-164)

🎯 Betting Tip: The Seahawks are +9.3 points against the spread on average this year (best in NFL), and coach Mike Macdonald is 8-3-1 ATS in road games since 2024.

Sunday | 4:05 PM ET | San Francisco 49ers vs. Arizona Cardinals

• Spread: SF -2.5
• Total: 48.5
• Moneyline: 49ers (-152); Cardinals (+128)

🎯 Betting Tip: Arizona coach Jonathan Gannon is 8-5 ATS (61.5%) as a home underdog since 2023.

Sunday | 4:25 PM ET | Kansas City Chiefs vs. Denver Broncos

• Spread: KC -3.5
• Total: 44.5
• Moneyline: Chiefs (-200); Broncos (+168)

🎯 Betting Tip: Patrick Mahomes is 6-1 after a regular-season bye week in his career with the Chiefs (only loss: 21-17 vs. 2023 Eagles on Monday Night Football). Use the Bet365 Kansas bonus code for $200 in bonus bets guaranteed.

Sunday | 4:25 PM ET | Baltimore Ravens vs. Cleveland Browns

• Spread: BAL -8.5
• Total: 39.5
• Moneyline: Ravens (-450); Browns (+350)

🎯 Betting Tip: Last week in Minnesota was Lamar Jackson's first game this season where he didn't take multiple sacks (sacked 3 times vs. Browns in Week 2).

Sunday | 8:20 PM ET | Detroit Lions vs. Philadelphia Eagles

• Spread: PHI -2.5
• Total: 46.5
• Moneyline: Lions (+124); Eagles (-144)

🎯 Betting Tip: Since 2022, Lions coach Dan Campbell is 13-6 ATS (68.4%) as an underdog, the best record in the NFL in that time.

Monday | 8:15 PM ET | Dallas Cowboys vs. Las Vegas Raiders

• Spread: DAL -3.5
• Total: 50.5
• Moneyline: Cowboys (-196); Raiders (+164)

🎯 Betting Tip: The average Raiders game has finished 4.7 points below the total line, the worst in the NFL this year (average Dallas game is +10.8 points above the total, the second-highest mark in 2025).

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