The 2025 college football regular season is down to the final two weeks as we head into Week 13. There are high-profile games between ranked teams with College Football Playoff implications, including a Big Ten showdown between No. 15 USC and No. 7 Oregon, also known as a classic Pac-10 matchup to old-school fans.

Here are the college football lines this week for the top 25 teams, accompanied by spreads, over/unders, top storylines, and our quick betting notes for each game.

College Football Lines This Week

Game
Spread
Total

Rutgers at #1 Ohio State
OSU -31.5
54.5
Samform at #3 Texas A&M
TA&M -55.5
N/A
#22 Missouri at #8 Oklahoma
OU -7.5
42.5
#13 Miami at Virginia Tech
MIA -17.5
48.5
Charlotte at #4 Georgia
UGA -43.5
52.5
Eastern Illinois at #10 Alabama
N/A
N/A
#15 USC at #7 Oregon
ORE -9.5
59.5
Syracuse at #9 Notre Dame 
ND -35.5
50.5
Kentucky at #14 Vanderbilt
VAN -9.5
53.5
Arkansas at #17 Texas
TEX -8.5
57.5
#24 Tulane at Temple
TULN -7.5
56.5
Kansas State at #12 Utah
UTAH -17.5
52.5
#18 Michigan at Maryland 
MICH -13.5
45.5
TCU at #23 Houston
HOU -1.5
54.5
Pittsburgh at #16 Georgia Tech
GT -2.5
61.5
#20 Tennessee at Florida
TENN -3.5
57.5
#21 Illinois at Wisconsin
ILL -7.5
40.5
#11 BYU at Cincinnati
BYU -2.5
54.5
#25 Arizona State at Colorado
ASU -6.5
48.5

CFB Betting Lines for Week 13: Odds, Storylines & Betting Tips

CFB Week 13 features only two games between ranked teams, but they are expected to be big games for the SEC and Big Ten.

In Saturday's noon window, you can see if No. 1 Ohio State and No. 3 Texas A&M both improve to 11-0 as huge favorites in their games, or you can tune into the most exciting matchup between No. 22 Missouri (7-3) and No. 8 Oklahoma (8-2) with the Sooners coming off that big win over Alabama last week as they look to lock up a playoff spot.

At 3:30 PM, change the channel to CBS to see No. 15 USC and quarterback Jayden Maiava going up against No. 7 Oregon in Eugene in what could be an explosive game with a total set to 59.5 points. ABC may also have some fireworks with No. 17 Texas hosting an Arkansas Razorbacks team that boasts a positive scoring differential despite a tough schedule and a 2-8 record this year. Meanwhile, FOX might have a tight one between TCU and No. 23 Houston in the game with the smallest spread in this slate.

In the evening, ESPN has Pittsburgh taking on No. 16 Georgia Tech in the ACC after the Yellow Jackets struggled with Boston College last week, and the Panthers were blown out at home by Notre Dame. ABC will have the classic SEC rivalry between No. 20 Tennessee and Florida, with the Volunteers a slight road favorite. You can also see on FOX if No. 11 BYU (9-1) can win again on the road against Cincinnati in an important game for the Big 12 race.

New sportsbook customers can sign up and get hundreds of dollars in college football betting promos for this weekend's games.

Saturday |12:00 PM ET | Rutgers vs. Ohio State

  • Spread: OSU -31.5
  • Total: 51.5
  • Moneyline: Off the book
🎯 Betting Tip: Ohio State is 8-1-1 ATS with an average margin of victory of 30.0 points this season.

Saturday| 12:00 PM ET | Samford vs. Texas A&M

  • Spread: TA&M -55.5
  • Total: Off the book
  • Moneyline: Off the book
🎯 Betting Tip: Texas A&M is 5-5 ATS and needed a 30-3 comeback at home last week to defeat South Carolina.

Saturday | 12:00 PM ET | Missouri vs. Oklahoma

  • Spread: OU -7.5
  • Total: 42.5
  • Moneyline: Missouri (+240); Oklahoma (-300)
🎯 Betting Tip: Both schools are 5-4-1 ATS, but Oklahoma is beating the spread by an average of +1.5 points to +2.9 points against Missouri.

Saturday | 12:00 PM ET | Miami FL vs. Virginia Tech

  • Spread: MIA -17.5
  • Total: 48.5
  • Moneyline: Miami (-1250); Virginia Tech (+740)
🎯 Betting Tip: Miami is 6-4 ATS but is on the bubble for making the college football playoffs.

Saturday | 12:45 PM ET | Charlotte vs. Georgia

  • Spread: UGA -43.5
  • Total: 52.5
  • Moneyline: Off the book
🎯 Betting Tip: Georgia is 5-5 ATS with an average game seeing them beat the spread by just +0.6 points. However, Charlotte is just 2-6-2 ATS this season.

Saturday | 2:00 PM ET | Eastern Illinois vs. Alabama

  • Spread: Off the book
  • Total: Off the book
  • Moneyline: Off the book
🎯 Betting Tip: Since 2024, Alabama is 3-1 ATS after a straight-up loss with an average margin of victory of 30.8 points.

Saturday | 3:30 PM ET | USC vs. Oregon

  • Spread: ORE -9.5
  • Total: 59.5
  • Moneyline: USC (+280); Oregon (-360)
🎯 Betting Tip: Since 2024, Oregon is 4-2 ATS against ranked opponents (USC is 4-3 ATS in such games).

Saturday | 3:30 PM ET | Syracuse vs. Notre Dame

  • Spread: ND -35.5
  • Total: 50.5
  • Moneyline: Off the books
🎯 Betting Tip: Syracuse is 3-3 ATS against ranked opponents since 2024.

Saturday | 3:30 PM ET | Kentucky vs. Vanderbilt

  • Spread: VAN -9.5
  • Total: 53.5
  • Moneyline: Kentucky (+285); Vanderbilt (-365)
🎯 Betting Tip: Vanderbilt is 7-2-1 ATS this season with an average margin of victory of 16.1 points per game.

Saturday | 3:30 PM ET | Arkansas vs. Texas

  • Spread: TEX -8.5
  • Total: 57.5
  • Moneyline: Arkansas (+275); Texas (-350)
🎯 Betting Tip: Arkansas (4-6 ATS) has lost four games by one score to ranked opponents this year, while Texas is just 2-7-1 ATS.

Saturday | 3:45 PM ET | Tulane vs. Temple

  • Spread: TULN -7.5
  • Total: 56.5
  • Moneyline: Tulane (-320); Temple (+255)
🎯 Betting Tip: Temple is 7-3 ATS this season while Tulane is only 4-5-1 ATS.

Saturday | 4:00 PM ET | Kansas State vs. Utah

  • Spread: UTAH -17.5
  • Total: 52.5
  • Moneyline: Kansas State (+610); Utah (-950)
🎯 Betting Tip: Kansas State (4-6 ATS) has underperformed against the spread by an average of 3 points. Utah is 8-2 ATS with the best performance above the spread in the nation (+11.6 points).

Saturday | 4:00 PM ET | Michigan vs. Maryland

  • Spread: MICH -13.5
  • Total: 45.5
  • Moneyline: Michigan (-650); Maryland (+460)
🎯 Betting Tip: Michigan is just 3-7 ATS this season, including a 1-4 ATS record as a road team.

Saturday | 4:00 PM ET | TCU vs. Houston

  • Spread: HOU -1.5
  • Total: 54.5
  • Moneyline: TCU (-104); Houston (-115)
🎯 Betting Tip: TCU is 4-5-1 ATS with an average spread difference of -4.9 points. Houston is 7-3 ATS with an average spread difference of +1.7 points.

Saturday | 7:00 PM ET | Pittsburgh vs. Georgia Tech

  • Spread: GT -2.5
  • Total: 61.5
  • Moneyline: Pittsburgh (+112); Georgia Tech (-134)
🎯 Betting Tip: Pittsburgh is 7-3 ATS but just 5-10 ATS following a loss since 2023 (1-1 ATS in 2025 after losses).

Saturday | 7:30 PM ET | Tennessee vs. Florida

  • Spread: TENN -3.5
  • Total: 57.5
  • Moneyline: Tennessee (-184); Florida (+152)
🎯 Betting Tip: Florida is 3-3 ATS against ranked opponents this season with an average margin of defeat of -8.7 points. Get $150 in bonus bets by signing up and wagering on the game with the Bet365 Tennessee bonus code.

Saturday | 7:30 PM ET | Illinois vs. Wisconsin

  • Spread: ILL -8.5
  • Total: 40.5
  • Moneyline: Illinois (-330); Wisconsin (+260)
🎯 Betting Tip: Wisconsin is 3-2 ATS against ranked opponents this season.

Saturday | 8:00 PM ET | BYU vs. Cincinnati

  • Spread: BYU -2.5
  • Total: 54.5
  • Moneyline: BYU (-138); Cincinnati (+115)
🎯 Betting Tip: Cincinnati and BYU are both 1-1 ATS against ranked teams this year.

Saturday | 8:00 PM ET | Arizona State vs. Colorado

  • Spread: ASU -6.5
  • Total: 48.5
  • Moneyline: Arizona State (-265); Colorado (+215)
🎯 Betting Tip: Since 2023, Deion Sanders' Colorado Buffaloes are 8-2 ATS against ranked opponents.
FanDuel Odds for CFB Week 13

Gambling Problem? Call 1-800-GAMBLER

21+ | Please Gamble Responsibly | Help is Available