Another week, another round of significant injuries across the NFL.

As teams begin to game plan for the playoffs, several will be doing so without key contributors.

From high-ankle sprains to potential season enders, here is a comprehensive look at the most impactful injuries from the past week of action and the initial timelines for their return.

Be sure to bookmark our NFL Injured Reserve Tracker, which will be updated weekly throughout the season.

Don't Miss Out on the Best Betting Recommendations Available

Warren Sharp is entering his 20th year providing winning betting recommendations to clients.

A $100 bettor has won $9,271 following Warren’s picks so far this season, and he only gets better in the playoffs.

Click here to learn more about 2025 Postseason Betting Packages!

Biggest NFL Week 18 Injuries:

JJ McCarthy Injury Update

Vikings QB JJ McCarthy left the game with an injury to his throwing hand on Sunday and was seen on the sideline telling his teammates that he's done for the day.

McCarthy initially injured his hand back in Week 16 against the Giants and has also dealt with a concussion and an ankle sprain in his first year as a starter.

Cam Ward Injury Update

Titans QB Cam Ward exited in the first quarter on Sunday after suffering an injury to his throwing shoulder.

The 2025 first-overall draft pick had played 100% of the Titans offensive snaps coming into today.

Veteran backup Brandon Allen replaced Ward under center.

Brock Purdy Injury Update

49ers QB Brock Purdy took a hard hit on the final play of their loss to the Seahawks on Saturday night.

He stayed down on the ground for a while before heading to the medical tent.

After the game, coach Kyle Shanahan said the quarterback suffered a stinger and could have continued playing if the 49ers got the ball back.

Purdy also suffered a thumb injury during the game.

Those issues mean he could have his practice reps managed in the lead up to the Wild Card Round, but he should be ready to go for the playoff opener.

Other Notable Week 18 Injuries

  • 49ers LT Trent Williams and WR Ricky Pearsall sat out the game against the Seahawks. Pearsall should be good to go for the playoffs after getting in limited practices all week, but Williams is more of a question mark following three straight DNPs.
  • Jaguars WR Brian Thomas, Jr. was evaluated for a concussion after suffering a head injury, but was cleared and returned to the game.