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Top Football Games to Bet On This Weekend

There are some high-quality games in college football and the NFL this weekend. We have a preview of two of the best matchups, which you can use your sportsbook bonuses on this weekend.

Saturday | 3:30 PM ET | USC Trojans vs. Oregon Ducks (-10, O/U 59.5)

For those of a certain age, it still might be hard to view the No. 15 USC Trojans and No. 7 Oregon Ducks as Big Ten teams, because this is a classic Pac-10 matchup from back in the days of Reggie Bush and Joey Harrington. However, it's a Big Ten matchup in 2025 between highly ranked teams, even if we're more likely to see Ohio State vs. Indiana decide the conference championship.

Oregon controls its playoff destiny and should be a favorite to have a shot in the tournament after competing with Indiana in a tight game that didn't go its way earlier this season. But the Ducks are 9-1 and rank No. 7 in scoring offense and No. 6 in scoring defense. Given that their win over No. 3 Penn State doesn't look so impressive now, this is Oregon's last shot to register a signature win this regular season.

The Trojans (8-2), meanwhile, can point to this as their signature win if they can pull off the road upset. They have a high-flying offense for coach Lincoln Riley, with Jayden Maiava having a strong season with 286.8 passing yards per game, 18 touchdowns, and 6 interceptions. He's leading USC to 38.2 points per game, which ranks 10th in the nation. USC has won its last three games, but this is the first time this season it has faced a team ranked higher than No. 13.

USC is 2-2 on the road and has yet to lose by more than 10 points in a game, so its offense can give it a shot in this one.

Sunday| 8:20 PM ET | Tampa Bay Buccaneers vs. Los Angeles Rams (-6.5, O/U 49.5)

After beating Seattle last week, some believe the Los Angeles Rams (8-2) are the best team in the NFC and possibly the entire NFL this year, given the chaotic nature of the AFC. This would probably be close to a consensus view if the Rams hadn't blown a 19-point lead to the Eagles earlier this year, or if they hadn't lost to the 49ers' backups on a Thursday night. But they've won every other game, and quarterback Matthew Stafford is the odds-on favorite to win MVP with 27 touchdowns to 2 interceptions on the season.

The Tampa Bay Buccaneers were once 5-1, but after losses to teams like Detroit, New England, and Buffalo, it's fair to question if the Bucs are ready to compete for anything beyond another NFC South title. Even that is in doubt as the Panthers are close at 6-5. However, the Buccaneers have had to deal with numerous injuries surrounding quarterback Baker Mayfield, who will likely be without Mike Evans and may also be without running back Bucky Irving. The final injury report will determine if Chris Godwin can return. That puts a lot of pressure on rookie wideout Emeka Egbuka, who has looked great at times, but he is still just one player. Mayfield led four comeback wins earlier this year, but hasn't had the magic touch in these losses.

For this particular matchup that we've seen before in the playoffs in 2021 and 2023, Sean McVay usually has a great plan for Todd Bowles' exotic blitzing defense. Since the Buccaneers are usually great at stopping the run with Vita Vea up front, teams opt to throw the ball instead. McVay really stresses the passing game against Bowles, as his quarterbacks, whether it was Stafford or Jared Goff before him, will usually throw for over 300 yards in this matchup. This season, the Buccaneers are struggling to defend the pass, so it's even more enticing for Stafford to drop back and throw to Puka Nacua and Davante Adams at home against this defense.

Stafford has made great use of play-action passing, and the Rams have an underrated running game with Kyren Williams. A strong offensive line makes it all work, too. The,n when you have a strong pass rush on defense, they should put a lot of stress on Mayfield to score a lot of points without all his weapons and without playing his best football the last month.