This is it for the 2025 NFL regular season. Week 18 is here with the final 16 games to wrap up the playoff picture. We've compiled the NFL Week 18 lines for this weekend's matchups, including the Seahawks vs. 49ers, the Texans vs. Colts, and the Ravens vs. Steelers.

Here are the NFL Week 18 lines, along with the spreads, totals, key storylines, and a betting fact for each game on the schedule.

NFL Lines Week 18 At a Glance

Game
Spread
Total

Panthers at Buccaneers(Saturday Afternoon)
TB -3
44.5
Seahawks at 49ers(Saturday Night)
SEA -1.5
49.5
Saints at Falcons
ATL -3
44.5
Browns at Bengals
CIN -7.5
44.5
Cowboys at Giants
DAL -3.5
52.5
Packers at Vikings
MIN -5.5
36.5
Colts at Texans
HOU -10.5
39.5
Titans at Jaguars
JAX -12.5
47.5
Chiefs at Raiders
KC -5.5
36.5
Lions at Bears
CHI -3
49.5
Chargers at Broncos
DEN -11.5
36.5
Dolphins at Patriots
NE -10.5
45.5
Commanders at Eagles
PHI -7
41.5
Cardinals at Rams
LAR -7.5
45.5
Jets at Bills
BUF -7.5
38.5
Ravens at Steelers(SNF)
BAL -3.5
41.5

NFL Betting Lines Week 18: Spreads, Storylines & Things to Know

The NFL's Week 18 schedule packs in two games that will decide division titles this Saturday and the final 14 games on Sunday. By then, we'll know the full playoff bracket on the way to Super Bowl 60.

It gets started on Saturday with those battles for the NFC South and NFC West. First, the Tampa Bay Buccaneers (7-9) will try to pick themselves off the mat after going 1-7 since their bye week as they host the Carolina Panthers (8-8), who didn't look good last week against Seattle. This one is interesting as both teams have had a lot of close wins to get to this point, so we'll see who can get it done. If the Panthers win, they win the NFC South at 9-8. However, even if the Buccaneers win this game on Saturday, they must wait until Sunday afternoon to see if the Saints can beat the Falcons; otherwise, there will be three teams tied at 8-9, and the Panthers will win the NFC South. How fitting would that be?

Things are much simpler on Saturday night in the NFC West. It's the big one for the No. 1 seed between the Seattle Seahawks (13-3) and San Francisco 49ers (12-4). The winner not only wins the NFC West but also secures the top seed, which could be particularly important for the 49ers, as it means they wouldn't have to leave Levi's Stadium for five straight games, including Super Bowl 60 in February. This is a Week 1 rematch, but things should look different with all the injuries that have piled up for both teams. But right now, Brock Purdy comes in red hot, and we'll see if Sam Darnold can answer. If you recall, he was in this spot last year in Week 18 with Minnesota, with the No. 1 seed on the line in Detroit, and let's say things did not go well. But a win there would be huge for him and Seattle, the new Super Bowl favorite.

In the early Sunday afternoon window, we have the aforementioned game between the Falcons and Saints in Atlanta that could actually determine the NFC South winner. But the main point of contention here is the AFC South. If the Jacksonville Jaguars beat the Titans at home as a huge favorite, they win the AFC South. But should the Jaguars falter, then the Houston Texans can win the AFC South by earning their ninth-straight win over the Colts, who will be starting Riley Leonard instead of Philip Rivers for the final game of the season.

We also have a rushing title battle brewing between Jonathan Taylor and Buffalo's James Cook. Taylor trails Cook by 47 yards, so we'll see how that plays out, as Cook may want to rest with other Buffalo starters, like Josh Allen, in the 4:25 PM game between the Bills and Jets. Speaking of the Jets, more history can be made in that game as they are already the first defense in NFL history to go 16 straight games without intercepting a pass on defense. So, it could come down to Mitch Trubisky to keep that number clean for every passer to face the Jets this year.

In the late-afternoon window, the main games will decide the No. 1 seed in the AFC. The Denver Broncos (13-3) can earn it with a win over the Chargers, who will reportedly rest Justin Herbert with his hand injury, and the Chargers are content with the No. 7 seed. However, if the Broncos falter, the New England Patriots (13-3) can secure the top seed by beating the Miami Dolphins at home. We'll see if Drake Maye can lock up his MVP award, as the Rams may not play Matthew Stafford and the starters, depending on what happens Saturday in the NFC West. The Rams could be headed for a No. 6 seed. Elsewhere, it could be the final NFL game for Travis Kelce with the Chiefs taking on the Raiders in Las Vegas. That also could be the end of the line for coach Pete Carroll, 74, if the Raiders decide to part ways after a 2-win season.

Finally, Sunday night is Game 272 of the 2025 season in Pittsburgh. It's the great rivalry between the Pittsburgh Steelers and Baltimore Ravens, with the 40th meeting between coaches John Harbaugh and Mike Tomlin. Will it be the last? Rumors are swirling that the losing team could make a coaching move, especially if it's Baltimore, which is trying to recover from a 1-5 start. Meanwhile, it could be Aaron Rodgers' final NFL game if the Steelers lose, and he won't have D.K. Metcalf (suspended) again at wide receiver. However, the most significant question mark is whether Lamar Jackson (back) will return, or if the Ravens will try to lean on Tyler Huntley and Derrick Henry to save the season, as they did last week in Green Bay. The AFC North and the No. 4 seed are on the line here.

That said, let's go through the NFL Week 18 lines with the latest odds and a betting tip for each game. Register at the best NFL betting sites for over $8,000 from sportsbook promos.

Saturday| 4:30 PM ET | Carolina Panthers vs. Tampa Bay Buccaneers

  • Spread: TB -3
  • Total: 44.5
  • Moneyline: Panthers (+124); Buccaneers (-146)
🎯 Betting Fact: Tampa Bay is 1-5 ATS as a home favorite this season (Panthers: 3-3 ATS as road underdog).

Saturday| 8:00 PM ET | Seattle Seahawks vs. San Francisco 49ers

  • Spread: SEA -1.5
  • Total: 49.5
  • Moneyline: Seahawks (-122); 49ers (+104)
🎯 Betting Fact: The 49ers have either had a losing record or reached the NFC Championship Game (or better) in 22 straight seasons.

Sunday| 1:00 PM ET | New Orleans Saints vs. Atlanta Falcons

  • Spread: ATL -3
  • Total: 44.5
  • Moneyline: Saints (+140); Falcons (-166)
🎯 Betting Fact: The under is 11-5 in New Orleans games this season, the second-best record.

Sunday| 1:00 PM ET | Cleveland Browns vs. Cincinnati Bengals

  • Spread: CIN -7.5
  • Total: 44.5
  • Moneyline: Browns (+300); Bengals (-375)
🎯 Betting Fact: Myles Garrett will move heaven and earth to record 1.0 sacks to set the single-season record against QB Joe Burrow.

Sunday| 1:00 PM ET | Dallas Cowboys vs. New York Giants

  • Spread: DAL -3.5
  • Total: 52.5
  • Moneyline: Cowboys (-184); Giants (+154)
🎯 Betting Fact: It's the only game with a total over 50 points this week, and the over was a league-best 11-4-1 in Dallas games this season.

Sunday| 1:00 PM ET | Green Bay Packers vs. Minnesota Vikings

  • Spread: MIN -5.5
  • Total: 36.5
  • Moneyline: Packers (+220); Vikings (-270)
🎯 Betting Fact: The Packers are expected to rest starters and take the No. 7 seed in the playoffs.

Sunday | 1:00 PM ET | Indianapolis Colts vs. Houston Texans

  • Spread: HOU -10.5
  • Total: 39.5
  • Moneyline: Colts (+450); Texans (-600)
🎯 Betting Fact: The Texans have beaten the spread by an average of +4.7 points, the fourth-best mark in 2025.

Sunday | 1:00 PM ET | Tennessee Titans vs. Jacksonville Jaguars

  • Spread: JAX -12.5
  • Total: 47.5
  • Moneyline: Titans (+590); Jaguars (-850)
🎯 Betting Fact: The Jaguars are 11-5 ATS, tied for the best record this season.

Sunday | 4:25 PM ET | Kansas City Chiefs vs. Las Vegas Raiders

  • Spread: KC -5.5
  • Total: 36.5
  • Moneyline: Chiefs (-275); Raiders (+225)
🎯 Betting Fact: Travis Kelce needs 10 receiving yards to reach 13,000 for his career in what could be his final NFL game.

Sunday | 4:25 PM ET | Detroit Lions vs. Chicago Bears

  • Spread: CHI -3
  • Total: 49.5
  • Moneyline: Lions (+134); Bears (-158)
🎯 Betting Fact: After winning 15 straight games following a loss back to 2022, Detroit's Dan Campbell has lost three straight games this season.

Sunday | 4:25 PM ET | Los Angeles Chargers vs. Denver Broncos

  • Spread: DEN -11.5
  • Total: 36.5
  • Moneyline: Chargers (+570); Broncos (-820)
🎯 Betting Fact: The 2025 Broncos have won 12 games after trailing, the most in NFL history for one season.

Sunday | 4:25 PM ET | Miami Dolphins vs. New England Patriots

  • Spread: NE -10.5
  • Total: 45.5
  • Moneyline: Dolphins (+490); Patriots (-670)
🎯 Betting Fact: The Patriots are 3-2-1 ATS as a home favorite this season (Miami: 2-3 ATS as road underdog).

Sunday | 4:25 PM ET | Washington Commanders vs. Philadelphia Eagles

  • Spread: PHI -7
  • Total: 41.5
  • Moneyline: Commanders (+162); Eagles (-194)
🎯 Betting Fact: The over is just 6-10 in Philadelphia games this season.

Sunday | 4:25 PM ET | Arizona Cardinals vs. Los Angeles Rams

  • Spread: LAR -7.5
  • Total: 45.5
  • Moneyline: Cardinals (+280); Rams (-350)
🎯 Betting Fact: It's possible the Rams bench or pull starters quickly, so bet accordingly.

Sunday | 4:25 PM ET | New York Jets vs. Buffalo Bills

  • Spread: BUF -7.5
  • Total: 38.5
  • Moneyline: Jets (+290); Bills (-360)
🎯 Betting Fact: The 2025 Jets are the only defense in NFL history to go 16 straight games without an interception.

Sunday| 8:20 PM ET | Baltimore Ravens vs. Pittsburgh Steelers

  • Spread: BAL -3.5
  • Total: 41.5
  • Moneyline: Ravens (-184); Steelers (+154)
🎯 Betting Fact: Aaron Rodgers has lost his last three home games with the season on the line (2020 NFC Championship Game vs. Buccaneers, 2021 NFC Divisional vs. 49ers, 2022 Week 18 vs. Lions for wild card berth).
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