The 2025 college football regular season heads into Week 12, with a few make-or-break games remaining for teams in the College Football Playoff hunt. There are several high-profile matchups between ranked teams, including two great SEC showdowns: No. 4 Alabama vs. No. 11 Oklahoma and No. 10 Texas vs. No. 5 Georgia.

Here are the college football lines this week for top 25 teams, accompanied by spreads, over/unders, top storylines, and our expert betting tips.

College Football Lines This Week

Game
Spread
Total

Clemson at #20 Louisville(Friday)
LOU -2.5
51.5
Minnesota at #8 Oregon(Friday)
ORE -25.5
44.5
#9 Notre Dame at #22 Pittsburgh
ND -12.5
55.5
Arizona at #25 Cincinnati
CIN -6.5
56.5
#24 South Florida at Navy
USF -10.5
64.5
Wisconsin at #2 Indiana
IU -29.5
43.5
South Carolina at #3 Texas A&M
TA&M -18.5
47.5
#18 Michigan at Northwestern
MICH -11.5
41.5
NC State at #15 Miami FL
MIA -14.5
55.5
#19 Virginia at Duke
DUKE -5.5
58.5
UCF at #6 Texas Tech
TTU -23.5
47.5
#11 Oklahoma at #4 Alabama
ALA -5.5
46.5
#16 Georgia Tech at Boston College
GT -16.5
58.5
#21 Iowa at #17 USC
USC -6.5
49.5
New Mexico State at #23 Tennessee
TENN -40.5
61.5
#13 Utah at Baylor
UTAH -8.5
60.5
Florida at #7 Ole Miss
MISS -15.5
53.5
UCLA at #1 Ohio State
OSU -33.5
48.5
#10 Texas at #5 Georgia
UGA -5.5
48.5
TCU at #12 BYU
BYU -4.5
52.5

CFB Betting Lines for Week 12: Odds, Storylines & Betting Tips

CFB Week 12 already has multiple ranked teams in action this Friday night when No. 20 Louisville (7-2) tries to hand Clemson (4-5) another ACC loss. No. 8 Oregon is also a big favorite to improve to 9-1 in the Big Ten against Minnesota.

In Saturday's noon window, you might see some real fireworks between young quarterbacks when No. 9 Notre Dame heads on the road to take on No. 22 Pittsburgh. Who will come out on top between freshman quarterbacks CJ Carr and Mason Heintschel.

At 3:30 PM, ABC has the big one in the SEC when No. 4 Alabama and quarterback Ty Simpson host No. 11 Oklahoma. The Crimson Tide has not lost since Week 1 as they eye a high playoff seed with another quality win. There's also an interesting Big Ten matchup when No. 17 USC and its high-flying offense takes on the stout defense of No. 21 Iowa.

In the evening, the big one is No. 10 Texas vs. No. 5 Georgia Bulldogs in another epic SEC clash. We'll also see No. 1 Ohio State as a heavy favorite against UCLA, and the BYU Cougars (8-1) have a good challenge from TCU at 10:15 PM.

New sportsbook users can sign up at college football betting sites to get loads of bonuses to use on CFB games this week.

Friday | 9:00 PM ET | Clemson vs. Louisville

  • Spread: LOU -2.5
  • Total: 51.5
  • Moneyline: Clemson (+118); Louisville (-138)
🎯 Betting Tip: In 2024, Louisville defeated Clemson 33-21 and held quarterback Cade Klubnik to 4.1 yards per pass attempt (second lowest of career).

Friday| 9:00 PM ET | Minnesota vs. Oregon

  • Spread: ORE -25.5
  • Total: 44.5
  • Moneyline: Minnesota (+1600); Oregon (-4500)
🎯 Betting Tip: Oregon is 3-2 ATS as a 25-point favorite this season (5-4 ATS overall).

Saturday | 12:00 PM ET | Notre Dame vs. Pittsburgh

  • Spread: ND -12.5
  • Total: 55.5
  • Moneyline: Notre Dame (-490); Pittsburgh (+380)
🎯 Betting Tip: Pittsburgh is 7-2 ATS and has outperformed the spread by an average of +8.1 points (ranked 10th in the nation).

Saturday | 12:00 PM ET | Arizona vs. Cincinnati

  • Spread: CIN -6.5
  • Total: 56.5
  • Moneyline: Arizona (+176); Cincinnati (-210)
🎯 Betting Tip: Cincinnati is 4-2 ATS as a favorite and Arizona is 1-2 ATS as an underdog this season.

Saturday | 12:00 PM ET | South Florida vs. Navy

  • Spread: USF -10.5
  • Total: 64.5
  • Moneyline: South Florida (-430); Navy (+340)
🎯 Betting Tip: The over is 6-1 in South Florida's last 7 games.

Saturday | 12:00 PM ET | Wisconsin vs. Indiana

  • Spread: IU -29.5
  • Total: 43.5
  • Moneyline: Wisconsin (+2400); Indiana (-10000)
🎯 Betting Tip: Those in Indiana should sign up with the Bet365 bonus code Indiana to claim $200 in free bets.

Saturday | 12:00 PM ET | South Carolina vs. Texas A&M

  • Spread: TA&M -18.5
  • Total: 47.5
  • Moneyline: South Carolina (+870); Texas A&M (-1500)
🎯 Betting Tip: Texas A&M's average margin of victory is 14.9 this season.

Saturday | 12:00 PM ET | Michigan vs. Northwestern

  • Spread: MICH -11.5
  • Total: 41.5
  • Moneyline: Michigan (-500); Northwestern (+385)
🎯 Betting Tip: Michigan is just 3-6 ATS this season, including a 2-4 ATS record as a favorite.

Saturday | 3:30 PM ET | NC State vs. Miami FL

  • Spread: MIA -14.5
  • Total: 55.5
  • Moneyline: NC State (+460); Miami FL (-650)
🎯 Betting Tip: Miami is 5-4 ATS and has outperformed the spread by an average of just +0.6 points per game.

Saturday | 3:30 PM ET | Virginia vs. Duke

  • Spread: DUKE -5.5
  • Total: 58.5
  • Moneyline: Virginia (+164); Duke (-200)
🎯 Betting Tip: Duke is 3-3 ATS as a favorite this season (0-2 as a favorite of at least 5 points).

Saturday | 3:30 PM ET | UCF vs. Texas Tech

  • Spread: TTU -23.5
  • Total: 47.5
  • Moneyline: UCF (+1280); Texas Tech (-3500)
🎯 Betting Tip: Texas Tech has scored at least 42 points in every home game against teams not ranked in the top 10 this season (5-0).

Saturday | 3:30 PM ET | Oklahoma vs. Alabama

  • Spread: ALA -5.5
  • Total: 46.5
  • Moneyline: Oklahoma (+172); Alabama (-210)
🎯 Betting Tip: Oklahoma is 4-4-1 ATS with an average difference of +0.7 points, and Alabama is 6-2-1 ATS with an average difference of +3.4 points.

Saturday | 3:30 PM ET | Georgia Tech vs. Boston College

  • Spread: GT -16.5
  • Total: 58.5
  • Moneyline: Georgia Tech (-950); Boston College (+610)
🎯 Betting Tip: Georgia Tech has not won a road game by more than 9 points this season (0-4 against a spread of double digits on the road).

Saturday | 3:30 PM ET | Iowa vs. USC

  • Spread: USC -6.5
  • Total: 49.5
  • Moneyline: Iowa (+215); USC (-265)
🎯 Betting Tip: Iowa has held three ranked opponents to 20 points or fewer this season and has yet to allow more than 28 points in any game.

Saturday | 4:15 PM ET | New Mexico State vs. Tennessee

  • Spread: TENN -40.5
  • Total: 61.5
  • Moneyline: Off the books
🎯 Betting Tip: The Volunteers average more than twice as many points as New Mexico State this year (43.6 vs. 21.3).

Saturday | 7:00 PM ET | Utah vs. Baylor

  • Spread: UTAH -8.5
  • Total: 60.5
  • Moneyline: Utah (-320); Baylor (+255)
🎯 Betting Tip: Baylor has allowed at least 41 points in both games against ranked opponents this year.

Saturday | 7:00 PM ET | Florida vs. Ole Miss

  • Spread: MISS -15.5
  • Total: 53.5
  • Moneyline: Florida (+570); Ole Miss (-850)
🎯 Betting Tip: Florida (3-6) has played the toughest strength of schedule in the 2025 CFB season and has lost 3-of-9 games by more than 15 points.

Saturday | 7:30 PM ET | UCLA vs. Ohio State

  • Spread: OSU -33.5
  • Total: 48.5
  • Moneyline: Off the books
🎯 Betting Tip: Ohio State is 7-1-1 ATS this season; only Texas Tech (9-1) is better among all FBS schools.

Saturday | 7:30 PM ET | Texas vs. Georgia

  • Spread: UGA -5.5
  • Total: 48.5
  • Moneyline: Texas (+164); Georgia (-200)
🎯 Betting Tip: Texas is just 2-6-1 ATS this season, but Arch Manning has thrown for over 325 yards and 3 touchdowns in each of his last two games.

Saturday | 10:15 PM ET | TCU vs. BYU

  • Spread: BYU -4.5
  • Total: 52.5
  • Moneyline: TCU (+146); BYU (-178)
🎯 Betting Tip: Since 2016, under coach Kalani Sitake, BYU is just 18-21-1 ATS after a loss (4-3-1 ATS since 2023).
FanDuel Odds for CFB Week 12

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