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Best NFL Week 15 Games to Bet

The NFL Week 15 schedule is filled with great games, including some key divisional matchups. We've selected two of the best games to give our betting previews.

Sunday | 1:00 PM ET | Buffalo Bills vs. New England Patriots (+1, O/U 49.5)

It's incredible to see a team win 10 straight games, already have a road win in hand over this opponent, and yet they are still a 1-point home underdog against a 9-4 Buffalo team that has already lost several games as a big favorite in 2025. But that's where we are in this upside-down 2025 season, where the Chiefs, Eagles, Ravens, and even the Bills, to an extent, are all struggling. However, the sportsbooks may not be fully sold on a team like the Patriots, who went from 4-13 last year to 11-2 under new coach Mike Vrabel and second-year quarterback Drake Maye. Vrabel is a Coach of the Year favorite, and Maye is right up there with Matthew Stafford in the MVP odds.

This game could go a long way in deciding many things, but at the top of the list is the literal AFC East title. If the Patriots win, they will be division champions, ending Buffalo's reign from 2020-24 that began after the New England dynasty ended. They'd be back on top of the AFC East, and they can thank an unexpected sweep of Buffalo for that. In the first meeting, the Patriots forced the Bills into some uncharacteristic turnovers, ending their streak of 26 games without losing the turnover battle. Drake Maye led his first and still only game-winning drive in the NFL that night, and the Patriots have been winning ever since.

Maye has never passed for 300 yards in an NFL game, but he has been close most weeks. He'll face a tough pass defense in the Bills, but he's already excelled once against them this year thanks to a huge game from No. 1 wideout Stefon Diggs, who will have to fill up the revenge tank one more time to bring home the division title this week.

Meanwhile, the Bills have been inconsistent, and Josh Allen's play has been erratic this season. The turnovers and sacks are way up from 2024, but the Bills are running the ball better than ever with James Cook, and they can always rely on Allen to bail them out with scrambles in tough situations like he did against the Bengals last week.

The Patriots are the only team this season that has yet to allow more than 27 points in any game, and they haven't allowed more than 23 points on defense yet. We'll see if they can keep their streaks alive and sweep the Bills, or if Buffalo has one final push left to hold onto the AFC East. But this is certainly the best competition they've had to face yet since Allen's breakout year in 2020.

Sunday | 1:00 PM ET | Baltimore Ravens vs. Cincinnati Bengals (+2.5, O/U 51.5)

Both teams lost tough one-score games in Week 14. The Ravens fell again to their hated rivals from Pittsburgh in a 27-22 final where they allowed Aaron Rodgers to throw for a season-high 284 passing yards without any running game. Rodgers hit four deep balls, something he didn't do once in the month of November, so Joe Burrow is probably licking his chops to get another shot at this defense. Burrow defeated the Ravens in his return game on Thanksgiving, throwing a ton of passes (32 by halftime) to shake off the rust while he watched his defense collect five turnovers to win 32-14, the worst margin of defeat for Lamar Jackson since 2021, which was also a game against the Bengals.

Cincinnati usually doesn't win these games with Baltimore, but it was close in both shootouts last year, and it can build on the Week 13 success here. But the Bengals lost 39-34 in Buffalo last week after Burrow threw a pick-six while leading in the fourth quarter, then his next pass was picked too. The Bills put them away with a big run by Josh Allen, so Jackson will need to use his legs more in this game, something he didn't look capable of doing on Thanksgiving.

But the Bengals rank 32nd in points allowed, a stat where Baltimore ranked 32nd early in the season. No one really expected these teams to have losing records going into this one in Week 15, but here we are after injuries to both quarterbacks and a lot of defensive issues.  But the Bengals are home this week, and that Baltimore defense has rarely been this vulnerable. However, we'll have to see if Tee Higgins can play after a second brush with a concussion. He missed the Thanksgiving game as well, so Burrow is used to not having him, and Ja'Marr Chase has often destroyed the Baltimore secondary as well.

Baltimore (6-7) still has realistic shot at winning the AFC North over Pittsburgh (7-6), but things start to look quite dire if they are swept by Baltimore, because they still have to face the Patriots and Packers, two teams vying for the No. 1 seeds, and they close Week 18 in Pittsburgh.