The race for College Football Playoff spots is heating up as we enter Week 11. We have some decisive games on tap, including a huge Big 12 battle between BYU and Texas Tech and an SEC matchup between LSU and Alabama.

Here are college football lines for the top 25, accompanied by spreads, over/unders, top storylines, and our expert betting tips.

College Football Lines This Week

Game
Spread
Total

Northwestern at #19 USC(Friday)
USC -14.5
50.5
#2 Indiana at Penn State
IU -14.5
48.5
#5 Georgia at Mississippi State
UGA -8.5
57.5
#7 BYU at #8 Texas Tech
TTU -10
52.5
#1 Ohio State at Purdue
OSU -29.5
47.5
#3 Texas A&M at #22 Missouri
TA&M -7.5
47.5
Syracuse at #18 Miami
MIA -28.5
45.5
#9 Oregon at #20 Iowa
ORE -6.5
41.5
Auburn at #16 Vanderbilt
VAN -6.5
47.5
#23 Washington at Wisconsin
WAS -11.5
45.5
Wake Forest at #14 Virginia
UVA -6.5
50.5
California at #15 Louisville
LOU -20.5
50.5
LSU at #4 Alabama
ALA -9.5
49.5
Navy at #10 Notre Dame
ND -26.5
55.5

CFB Betting Lines for Week 11: Odds, Storylines & Betting Tips

CFB Week 11 revs up Friday night when Jayden Maiava leads the No. 19 USC Trojans against Northwestern in a Big Ten battle. Lincoln Riley and the Trojans still have an outside shot of making the CFP, but have upcoming games against Iowa and Oregon on deck. A slip up here would kiss their chances goodbye.

In Saturday's noon window, we'll see Heisman hopeful Fernando Mendoza lead No. 2 Indiana into Happy Valley to take on a struggling Penn State team led by an interim coach. No. 5 Georgia squares off against Mississippi State on the road. Can the Bulldogs finally play a solid first half and not need to make a late comeback? Then Big Noon Kickoff features the No. 7 BYU Cougars (8-0) taking the Texas Tech Red Raiders (7-1) in a battle for Big 12 supremacy.

At 3:30 pm, you can catch No. 3 Texas A&M (8-0) attempting to stay perfect on the road against No. 22 Missouri, who will suit up for the first time without starting quarterback Beau Pribula, who suffered a gruesome leg injury against Vanderbilt. There's also a quality game in the Big Ten matchup between the No. 9 Oregon Ducks and No. 20 Iowa Hawkeyes.

In the evening, we'll see LSU in its first game after firing coach Brian Kelly, taking on No. 4 Alabama behind Heisman candidate Ty Simpson. Louisville (7-1) is a big favorite against Cal, and Notre Dame hosts Navy.

Bet on CFB Week 11 GAmes at BETMGM

Friday | 9:00 PM ET | Northwestern vs. USC

  • Spread: USC -14.5
  • Total: 50.5
  • Moneyline: Northwestern (+480); USC (-650)
🎯 Betting Tip: USC quarterback Jayden Maiava is coming off a season-low 135 passing yards vs. Nebraska (at least 230 yards in every other game this season).

Saturday | 12:00 PM ET | Indiana vs. Penn State

  • Spread: IU -14.5
  • Total: 48.5
  • Moneyline: Indiana (-800); Penn State (+560)
🎯 Betting Tip: Those in Indiana should sign up with the Bet365 bonus code Indiana to claim $200 in free bets.

Saturday | 12:00 PM ET | Georgia vs. Mississippi State

  • Spread: UGA -8.5
  • Total: 57.5
  • Moneyline: Georgia (-350); Mississippi State (+265)
🎯 Betting Tip: Georgia has only played two true road games this season and are 2-0 with a +13 scoring differential.

Saturday | 12:00 PM ET | BYU vs. Texas Tech

  • Spread: TTU -10.5
  • Total: 52.5
  • Moneyline: BYU (+260); Texas Tech (-320)
🎯 Betting Tip: Texas Tech (8-1 ATS) is on average +8.2 points above the spread this year compared to +7.7 for BYU (6-2 ATS).

Saturday | 1:00 PM ET | Ohio State vs. Purdue

  • Spread: OSU -29.5
  • Total: 48.5
  • Moneyline: Ohio State (-10000); Purdue (+3000)
🎯 Betting Tip: Ohio State is 7-0-1 ATS this season with an average margin of victory of 29.8 points.

Saturday | 3:30 PM ET | Texas A&M vs. Missouri

  • Spread: TA&M -7.5
  • Total: 47.5
  • Moneyline: Texas A&M (-275); Missouri (+220)
🎯 Betting Tip: Texas A&M is only 4-4 ATS this season compared to 4-3-1 ATS for Missouri.

Saturday | 3:30 PM ET | Syracuse vs. Miami FL

  • Spread: MIA -28.5
  • Total: 45.5
  • Moneyline: Syracuse (+3000); Miami (-10000)
🎯 Betting Tip: Miami has outperformed the spread by just +0.7 points per game this season (5-3 ATS).

Saturday | 3:30 PM ET | Oregon vs. Iowa

  • Spread: ORE -6.5
  • Total: 41.5
  • Moneyline: Oregon (-245); Iowa (+198)
🎯 Betting Tip: Iowa is 5-2-1 ATS with +8.1 spread value on average (ranked 10th in the nation).

Saturday | 4:00 PM ET | Auburn vs. Vanderbilt

  • Spread: VAN -6.5
  • Total: 45.5
  • Moneyline: Auburn (+198); Vanderbilt (-245)
🎯 Betting Tip: Auburn is only 3-5-1 ATS while Vanderbilt is 6-2-1 ATS with an average +9.2 points above the spread line (ranked 7th in the nation).

Saturday | 4:30 PM ET | Washington vs. Wisconsin

  • Spread: WAS -11.5
  • Total: 45.5
  • Moneyline: Washington (-430); Wisconsin (+330)
🎯 Betting Tip: Wisconsin has underperformed the spread by -6.4 points this year (3-5 ATS).

Saturday | 7:00 PM ET | Wake Forest vs. Virginia

  • Spread: UVA -6.5
  • Total: 47.5
  • Moneyline: Wake Forest (+205); Virginia (-255)
🎯 Betting Tip: Virginia is 3-1 ATS at home this season.

Saturday | 7:00 PM ET | California vs. Louisville

  • Spread: LOU -20.5
  • Total: 50.5
  • Moneyline: California (+890); Louisville (-1700)
🎯 Betting Tip: Despite the good team record, Louisville is 0-5 ATS at home this season.

Saturday | 7:30 PM ET | LSU vs. Alabama

  • Spread: ALA -9.5
  • Total: 49.5
  • Moneyline: LSU (+310); Alabama (-400)
🎯 Betting Tip: Since 2024, Alabama is 8-2 ATS as a home favorite.

Saturday | 7:30 PM ET | Navy vs. Notre Dame

  • Spread: ND -26.5
  • Total: 55.5
  • Moneyline: Navy (+1400); Notre Dame (-4000)
🎯 Betting Tip: Notre Dame defeated Navy 51-14 last season and 42-3 in 2023.
FanDuel Week 11 NCAAF odds

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