We had more close games in the NFL last week, including the upset of the year by point spread with the Panthers beating the Packers (-13.5). Fans will hope to see more madness in NFL Week 10, with the game of the week coming on Monday night when the Packers host the Eagles.

Here are the NFL Week 10 lines, accompanied by spreads, over/unders, top storylines, and our betting tips.

NFL Lines Week 10 At a Glance

Game
Spread
Total

Raiders at Broncos(TNF)
DEN -9.5
42.5

Falcons at Colts (Germany)

IND -6.5
 48.5
Jaguars at Texans
HOU -1.5
38.5
Giants at Bears
CHI -3.5
48.5
Ravens at Vikings
BAL -4.5
47.5
Browns at Jets
NYJ +2.5
37.5
Saints at Panthers
CAR -5.5
39.5
Bills at Dolphins
BUF -9.5
49.5
Patriots at Buccaneers
TB -2.5
48.5
Cardinals at Seahawks
SEA -6.5
45.5
Rams at 49ers
LAR -3.5
50.5
Lions at Commanders
DET -8.5
49.5
Steelers at Chargers(SNF)
LAC -3
45.5
Eagles at Packers(MNF)
GB -2.5
44.5

NFL Betting Lines Week 10: Spreads, Storylines & Betting Tips

The Colts and Packers both entered last week with the best records in the NFL before losing. Those results, along with a string of other high-profile upsets, have us reevaluating teams heading into Week 10. It's been a crazy season already, and nothing defines craziness more than the Kansas City Chiefs, who are just 5-4, having the best odds of any team to win Super Bowl LX even though they would miss the playoffs (No. 8 seed) if they started today.

But Week 10 could be the week for some teams to prove how big a contender they really are. The Broncos (7-2) will try to win a normal game for a change as a big favorite against the Raiders on Thursday night, but with Brock Bowers back and Patrick Surtain II still out for the Denver defense, don't be surprised if this one is closer than expected.

To start NFL Sunday this week, the Colts and Falcons will meet in Berlin, Germany. The Colts made a huge splash after trading two first-round picks to the Jets for cornerback Sauce Gardner, which could be a massive move in keeping them on top of the AFC this year. However, they'll have to contend with a strong Atlanta defense that is still seeking its first win since defeating Josh Allen and the Bills a month ago.

Sunday afternoon features a good matchup between the Ravens and Vikings, with Lamar Jackson and J.J. McCarthy back in time for a crucial game between teams trying to get on track for the playoffs. We'll also get a 49ers vs. Rams rematch from a few weeks back when the shorthanded 49ers shocked the Rams in overtime.

Sunday Night Football sees the Steelers on the road against Jim Harbaugh's LA Chargers. These teams met last year, and a gimpy Justin Herbert left the 20-10 loss in the third quarter. Now with Joe Alt suffering a season-ending ankle injury, we'll see if the Chargers can protect Herbert against a Pittsburgh defense that has forced 11 turnovers in wins.

Finally, Monday night was supposed to be the huge one between the Eagles and Packers, but Green Bay's shocking loss to Carolina, combined with a torn ACL ending tight end Tucker Kraft's season, casts some serious doubt on the Packers as a Super Bowl favorite. We'll see if they can get past a Philadelphia team that swept them out of the playoffs last year.

That said, let's break down the NFL Week 10 lines with the latest odds and an expert tip for each game.

Thursday | 8:15 PM ET | Las Vegas Raiders vs. Denver Broncos

  • Spread: DEN -9.5
  • Total: 42.5
  • Moneyline: Raiders (+385); Broncos (-500)
🎯 Betting Tip: Since 2023, Sean Payton's Broncos are 7-5-1 ATS in division games vs. AFC West opponents.

Sunday | 9:30 AM ET | Atlanta Falcons vs. Indianapolis Colts

  • Spread: IND -6.5
  • Total: 48.5
  • Moneyline: Falcons (+220); Colts (-270)
🎯 Betting Tip: The Colts had more turnovers (6) in Pittsburgh than the first eight games combined (4) this season.

Sunday | 1:00 PM ET | Jacksonville Jaguars vs. Houston Texans

  • Spread: HOU -1.5
  • Total: 38.5
  • Moneyline: Jaguars (-102); Texans (-116)
🎯 Betting Tip: Since 2023, DeMeco Ryans is 6-8-1 ATS as a home favorite, the seventh-worst record in that time.

Sunday | 1:00 PM ET | New York Giants vs. Chicago Bears

  • Spread: CHI -3.5
  • Total: 48.5
  • Moneyline: Giants (+162); Bears (-194)
🎯 Betting Tip: Chicago rookie coach Ben Johnson is 2-0 ATS as a favorite this season.

Sunday | 1:00 PM ET | Baltimore Ravens vs. Minnesota Vikings

  • Spread: BAL -4.5
  • Total: 47.5
  • Moneyline: Ravens (-215); Vikings (+180)
🎯 Betting Tip: Since 2022, Vikings coach Kevin O'Connell is 11-6-2 ATS in non-conference games (tied for fourth-best record in that span).

Sunday | 1:00 PM ET | Cleveland Browns vs. New York Jets

  • Spread: CLE -2.5
  • Total: 37.5
  • Moneyline: Browns (-134); Jets (+114)
🎯 Betting Tip: Since 2021, Kevin Stefanski is 2-7 ATS as a road favorite for the Browns; the third-worst mark in that span.

Sunday | 1:00 PM ET | New Orleans Saints vs. Carolina Panthers

  • Spread: CAR -5.5
  • Total: 39.5
  • Moneyline: Saints (+205); Panthers (-250)
🎯 Betting Tip: Of Carolina quarterback Bryce Young's 11 career wins, nine have come from a game-winning drive in the fourth quarter or overtime.

Sunday | 1:00 PM ET | Buffalo Bills vs. Miami Dolphins

  • Spread: BU F -9.5
  • Total: 49.5
  • Moneyline: Bills (-510); Dolphins (+390)
🎯 Betting Tip: Despite winning the AFC East every year since 2020, Buffalo is only 17-17-1 ATS in division games vs. AFC East (1-2 ATS this year).

Sunday | 1:00 PM ET | New England Patriots vs. Tampa Bay Buccaneers

  • Spread: TB -2.5
  • Total: 48.5
  • Moneyline: Patriots (+120); Buccaneers (-142)
🎯 Betting Tip: Since 2023, Tampa coach Todd Bowles is 8-4 ATS against AFC opponents, tied for the fifth-best record.

Sunday | 4:05 PM ET | Arizona Cardinals vs. Seattle Seahawks

  • Spread: SEA -6.5
  • Total: 45.5
  • Moneyline: Cardinals (+260); Seahawks (-320)
🎯 Betting Tip: Seattle and the Rams are the only teams covering the spread 75% of the time (6-2) this season but Arizona +4.5 is a line that has hit in all eight of their games this year.

Sunday | 4:25 PM ET | Los Angeles Rams vs. San Francisco 49ers

  • Spread: LAR -3.5
  • Total: 50.5
  • Moneyline: Rams (-190); 49ers (+160)
🎯 Betting Tip: In division games since 2017, the Rams (Sean McVay) are 31-20-1 ATS (60.8%) and the 49ers (Kyle Shanahan) are 27-25-1 ATS (51.9%).

Sunday | 4:25 PM ET | Detroit Lions vs. Washington Commanders

  • Spread: DET -8.5
  • Total: 49.5
  • Moneyline: Lions (-480); Commanders (+370)
🎯 Betting Tip: The Commanders have been held under 15 points in consecutive games after a 27-game streak of scoring at least 18 points (tied for second longest in NFL history).

Sunday | 8:20 PM ET | Pittsburgh Steelers vs. Los Angeles Chargers

  • Spread: LAC -3
  • Total: 45.5
  • Moneyline: Steelers (+126); Chargers (-148)
🎯 Betting Tip: Since 2007, Mike Tomlin is 14-9 SU as a road underdog of no more than 3 points (8-3 since 2015).

Monday | 8:15 PM ET | Philadelphia Eagles vs. Green Bay Packers

  • Spread: GB -2.5
  • Total: 44.5
  • Moneyline: Eagles (+116); Packers (-136)
🎯 Betting Tip: Since 2021, the Chiefs (5-2) and Nick Sirianni's Eagles (6-5) are the only teams with a winning record (SU) when they're a road underdog.
FanDuel NFL Week 10 Odds

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