It's almost playoff time, and the NFL Week 16 features many games with postseason berths on the line. We've compiled the NFL Week 16 lines for this week's most crucial games, including the Rams vs. Seahawks, Packers vs. Bears, and Patriots vs. Ravens.

Here are the NFL Week 16 lines, along with the spreads, totals, key storylines, and a betting fact for each contest on the schedule.

NFL Lines Week 16 At a Glance

Game
Spread
Total

Rams at Seahawks(TNF)
LAR -1.5
44.5
Eagles at Commanders(Saturday Afternoon)
PHI -6.5
44.5
Packers at Bears(Saturday Night)
GB -1.5
46.5
Chargers at Cowboys
DAL -2.5
49.5
Vikings at Giants
MIN -2.5
43.5
Bills at Browns
BUF -10.5
42.5
Jets at Saints
NO -4.5
40.5
Buccaneers at Panthers
TB -3
45.5
Bengals at Dolphins
CIN -2.5
50,5
Chiefs at Titans
KC -3.5
37.5
Jaguars at Broncos
DEN -3
45.5
Falcons at Cardinals
ATL -2,5
47.5
Steelers at Lions
DET -6.5
51.5
Raiders at Texans
HOU -14.5
37.5
Patriots at Ravens(SNF)
BAL -2.5
47.5
49ers at Colts(MNF)
SF -6.5
46.5

NFL Betting Lines Week 16: Spreads, Storylines & Things to Know

The NFL Week 16 schedule is a strong one heading into Christmas week, featuring important matchups in both conferences. Don't forget we have two Saturday games this week, including a huge NFC North rematch.

It all starts Thursday night with the best game of the week on paper for the NFC West lead and possibly the No. 1 seed when the Los Angeles Rams try to sweep the Seattle Seahawks. They played a 21-19 game last month where the Rams escaped with the win despite intercepting Sam Darnold four times, so it's a huge opportunity for Darnold to get some revenge against the team that's given him fits since 2024. We are unlikely to see Davante Adams (hamstring) for the Rams on a short week after he left Sunday's game injured, and that's bad news as the Seahawks held MVP favorite Matthew Stafford to a season-low 130 passing yards with Adams. It's a game with many big stakes.

On Saturday, there's a double-header with a 5:00 PM kickoff between the Eagles and Commanders. The stakes aren't that high now that the Cowboys' only hope of winning the NFC East is to win out, while the Eagles (9-5) must lose out, but the Eagles can wrap up the NFC East with a win here, becoming the first team to repeat as NFC East champions since the Eagles did it in 2001-04. The Commanders have placed quarterback Jayden Daniels on injured reserve, ending his second season.

On Saturday night, it's the other major NFC game this week when the Chicago Bears (10-4) host the Green Bay Packers (9-4-1) for the NFC North lead. They just met two weeks ago, and the Bears made it a 28-21 game late with a shot at the touchdown in the closing seconds before Caleb Williams was intercepted in the end zone. But the Packers come in with serious injury issues after losing Micah Parsons to a torn ACL in Denver, and wideout Christian Watson may also not be able to return this week. The Bears stomped the Browns 31-3 with Williams looking impressive against that defense, and the Bears have 20 more takeaways than the Green Bay defense this year. They could steal this one and take a commanding lead in the NFC North with two games to go, which could help Ben Johnson win the Coach of the Year award if he pulls this off.

In the Sunday afternoon window, the marquee game is in Carolina, where the Panthers and Buccaneers battle as 7-7 teams coming off losses to maintain their grip on the NFC South lead. They'll meet again in Week 18, too, but it's a chance for Carolina to take the lead at home after slipping up in New Orleans last week. The Buccaneers are 1-5 since their bye week.

In the late-afternoon window, we'll see if the Detroit Lions (8-6) can get an important win against the Steelers (8-6), who have won two in a row and are starting to get the best games this year from Aaron Rodgers. However, the Lions need this one more, as they are not currently in the playoffs, presently holding the third-place spot in the NFC North. We'll also see the Jaguars (10-4) in Denver against the Broncos, who have by far the NFL's longest winning streak at 11 games after Bo Nix passed for four touchdowns to beat the Packers last week. Denver is inching closer to the No. 1 seed in the AFC playoffs, but don't sleep on the Jaguars, who have scored at least 25 points in every game since the bye week.

On Sunday Night Football, the NFL flexed Patriots vs. Ravens into prime time, giving Drake Maye some MVP love if he can pull out a road upset. Maye was held to a season-low 155 passing yards against Buffalo last week as the Patriots blew a 21-0 lead, snapping their 10-game winning streak. The AFC East is not wrapped up yet, so it's an important game for the Patriots, and the Ravens need to win at least one of these next two games to make sure they can play for the AFC North title in Pittsburgh in Week 18.

Lastly, Monday night could be a wild one as we're likely going to see Philip Rivers start a home game for the Colts as they host the 49ers, the quietest 10-4 team in the NFL, who has a chance to host the Super Bowl in February. We'll see if Rivers can improve on his first game in five years after he threw a touchdown in Seattle and led a late go-ahead field goal drive before the Seahawks came back to win 18-16.

That said, let's go through the NFL Week 16 lines with the latest odds and a betting tip for each game. Sign up at the best football betting sites for over $5,000 in sportsbook bonuses.

Thursday | 8:15 PM ET | Los Angeles Rams vs. Seattle Seahawks

  • Spread: LAR -1.5
  • Total: 44.5
  • Moneyline: Rams (-108); Seahawks (-108)
🎯 Betting Fact: Seahawks QB Sam Darnold is 0-3 against the Rams and 25-4 against the rest of the NFL since 2024.

Saturday | 5:00 PM ET | Philadelphia Eagles vs. Washington Commanders

  • Spread: PHI -6.5
  • Total: 44.5
  • Moneyline: Eagles (-295); Commanders  (+240)
🎯 Betting Fact: The Commanders were the only team to beat the Eagles after September in the 2024 season.

Saturday | 8:20 PM ET | Green Bay Packers vs. Chicago Bears

  • Spread: GB -1.5
  • Total: 46.5
  • Moneyline: Packers (-108); Bears (-108)
🎯 Betting Fact: The Packers are 1-5 ATS as a road favorite this season (Bears are 5-3 ATS as an underdog).

Sunday| 1:00 PM ET | Los Angeles Chargers vs. Dallas Cowboys

  • Spread: DAL -2.5
  • Total: 49.5
  • Moneyline: Chargers (+108); Cowboys (-126)
🎯 Betting Fact: The Cowboys are 2-5 ATS as a favorite this season (Chargers are 3-0 ATS as an underdog).

Sunday| 1:00 PM ET | Minnesota Vikings vs. New York Giants

  • Spread: MIN -2.5
  • Total: 43.5
  • Moneyline: Vikings (-152); Giants (+128)
🎯 Betting Fact: J.J. McCarthy has three road wins this year, where he threw two touchdowns and rushed for a score in each game.

Sunday| 1:00 PM ET | Buffalo Bills vs. Cleveland Browns

  • Spread: BUF -10.5
  • Total: 42.5
  • Moneyline: Bills (-620); Browns (+460)
🎯 Betting Fact: Cleveland's Myles Garrett has 21.5 sacks (single-season record is 22.5 sacks).

Sunday | 1:00 PM ET | New York Jets vs. New Orleans Saints

  • Spread: NO -4.5
  • Total: 40.5
  • Moneyline: Jets (+176); Saints (-210)
🎯 Betting Fact: The Saints are 1-1 ATS as a favorite in 2025 under rookie coach Kellen Moore. The Bet365 Louisiana promo offers new users $150 in guaranteed bonus bets.

Sunday | 1:00 PM ET | Tampa Bay Buccaneers vs. Carolina Panthers

  • Spread: TB -3
  • Total: 45.5
  • Moneyline: Buccaneers (-164); Panthers (+138)
🎯 Betting Fact: Since 2022, Tampa Bay coach Todd Bowles is 9-13 ATS (40.9%) in NFC South games.

Sunday | 1:00 PM ET | Cincinnati Bengals vs. Miami Dolphins

  • Spread: CIN -2.5
  • Total: 50.5
  • Moneyline: Bengals (-138); Dolphins (+118)
🎯 Betting Fact: Since 2021, the Bengals are 13-7 ATS (65%) as a road favorite under coach Zac Taylor.

Sunday | 1:00 PM ET | Kansas City Chiefs vs. Tennessee Titans

  • Spread: KC -3.5
  • Total: 37.5
  • Moneyline: Chiefs (-180); Titans (+152)
🎯 Betting Fact: The Chiefs have not played a game without Patrick Mahomes without resting starters for the playoffs since 2019 (finished 1-1). Use the Bet365 Kansas bonus code SHARP365 for up to $1,000 in bonus bets.

Sunday | 4:05 PM ET | Jacksonville Jaguars vs. Denver Broncos

  • Spread: DEN -3
  • Total: 45.5
  • Moneyline: Jaguars (+144); Broncos (-172)
🎯 Betting Fact: The Jaguars are 9-5 ATS (6-3 ATS after an outright win).

Sunday | 4:05 PM ET | Atlanta Falcons vs. Arizona Cardinals

  • Spread: ATL -2.5
  • Total: 47.5
  • Moneyline: Falcons (-152); Cardinals (+128)
🎯 Betting Fact: Arizona QB Jacoby Brissett has thrown nine touchdowns to tight end Trey McBride this season (Kyler Murray had 5 passing touchdowns to McBride in 2022-25).

Sunday | 4:25 PM ET | Pittsburgh Steelers vs. Detroit Lions

  • Spread: DET -6.5
  • Total: 51.5
  • Moneyline: Steelers (+270); Lions (-335)
🎯 Betting Fact: Lions coach Dan Campbell has won 15 straight games (14-1 ATS) following an outright loss.

Sunday | 4:25 PM ET | Las Vegas Raiders vs. Houston Texans

  • Spread: HOU -14.5
  • Total: 37.5
  • Moneyline: Raiders (+750); Texans (-1200)
🎯 Betting Fact: The 2021 Texans and 2025 Raiders are the only teams in the Super Bowl era to get shut out 31-0 or worse while throwing for no more than 70 yards in multiple games in one season.

Sunday | 8:20 PM ET | New England Patriots vs. Baltimore Ravens

  • Spread: BAL -2.5
  • Total: 47.5
  • Moneyline: Patriots (+130); Ravens (-154)
🎯 Betting Fact: Patriots QB Drake Maye has never thrown for 300 yards in an NFL game nor has he ever led a fourth-quarter comeback win when trailing by one score (0-7).

Monday | 8:15 PM ET | San Francisco 49ers vs. Indianapolis Colts

  • Spread: SF -6.5
  • Total: 46.5
  • Moneyline: 49ers (-300); Colts (+245)
🎯 Betting Fact: Sunday at Seattle ended a 106-game streak for Philip Rivers (120) throwing for at least 150 yards in an NFL game.
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