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It’s been six long months since Super Bowl 59, so a full docket of NFL preseason games is something every football fan is craving. Let's take a look at the NFL preseason odds for Week 1 games, suggested bets, which sportsbooks to use, and how to watch the games.

NFL 2025 Preseason Week 1 Schedule & Odds

It’s a four-day slate of NFL preseason action in Week 1. Here are the odds for each NFL preseason game this week at Bet365 (Odds correct at time of posting).

Thursday, August 7, 2025

  • 7:00 PM ET | Indianapolis Colts vs. Baltimore Ravens (-6.5, O/U 36.5)
  • 7:30 PM ET | Cincinnati Bengals vs. Philadelphia Eagles (+6.5, O/U 37)
  • 8:00 PM ET | Las Vegas Raiders vs. Seattle Seahawks (+6.5, O/U 37)
📌 Interesting note: Nick Sirianni typically opts not to play his starters in the preseason, which seems to pay dividends. The Eagles are 4-0 in regular season openers during his tenure.

Friday, August 8, 2025

  • 7:00 PM ET | Cleveland Browns vs. Carolina Panthers (-6.5, O/U 32.5)
  • 7:00 PM ET | Detroit Lions vs. Atlanta Falcons (+4, O/U 33)
  • 7:30 PM ET | Washington Commanders vs. New England Patriots (-6.5, O/U 34.5)
👉 Top player to watch: Browns rookie quarterback Shedeur Sanders is expected to get a lot of playing time after his historic slide from the first to fifth round in the NFL Draft.

Saturday, August 9, 2025

  • 1:00 PM ET | New York Giants vs. Buffalo Bills (+1.5, O/U 37.5)
  • 4:00 PM ET | Houston Texans vs. Minnesota Vikings (-1.5, O/U 38)
  • 7:00 PM ET | Dallas Cowboys vs. Los Angeles Rams (+2, O/U 33.5)
  • 7:00 PM ET | Pittsburgh Steelers vs. Jacksonville Jaguars (-2.5, O/U 36)
  • 7:30 PM ET | Tennessee Titans vs. Tampa Bay Buccaneers (+3.5, O/U 32.5)
  • 8:00 PM ET | Kansas City Chiefs vs. Arizona Cardinals (-1.5, O/U 38.5)
  • 8:00 PM ET | New York Jets vs. Green Bay Packers (-2.5, O/U 36.5)
  • 8:30 PM ET | Denver Broncos vs. San Francisco 49ers (-6, O/U 34.5)
❓ Where will he line up? Jaguars rookie Travis Hunter is going to be a top story all season, so it’ll be interesting to see if he plays wide receiver, cornerback, or both in his preseason debut against the Steelers.

Sunday, August 10, 2025

  • 1:00 PM ET | Miami Dolphins vs. Chicago Bears (-3, O/U 32.5)
  • 4:05 PM ET | New Orleans Saints vs. Los Angeles Chargers (+1, O/U 36.5)
🍿 Keep an eye on: Saints rookie quarterback Tyler Shough. He could make his NFL debut in Los Angeles against a Chargers defense that played fantastic against the Lions last week in the preseason Hall of Fame Game.

NFL Preseason week 1 odds at bet365

Odds correct at time of posting – Captured: August 7, 2025

How to Bet on NFL 2025 Preseason Week 1 Games

With these NFL preseason matches, you’ll find common betting markets for moneyline, spread, and total points. You can also bet on team props like the over/under for how many points one will score in the game.

There are some limited player props available, but with the NFL preseason, especially in Week 1, no one really knows who is going to play and for how long, so you likely won’t see good prop options or same game parlays this week.

General NFL Preseason Betting Tips

Here are some general betting tips to make the most of your NFL preseason betting opportunities this weekend:

  • It’s Week 1 of the preseason, so this is just for fun. You’ll want to conserve your bankroll for the crucial games, where you know what the lineups will look like.
  • Focus on moneylines and spreads for teams known to play their starters more in the preseason, like the Broncos and Titans.
  • Fade teams that blow off playing starters in the preseason, like the Rams and 49ers.
  • Research the quarterback depth charts for teams and base your spread/moneyline decisions on which team you think is stronger at that position.
  • For teams that like to rest starting offensive players, you could zero in on betting their team total to go under.
  • Expect most of the Week 1 game to be low-scoring, as teams are just getting back in the groove.

How to Place an NFL Preseason Bet

No matter which sportsbook you choose, you can take advantage of their new customer promo and wager on the top NFL preseason games this week. Here is a general step-by-step process to follow:

  1. Visit the mobile site or download the app of the sportsbook you want to join.
  2. Create a new user account by entering your personal information (name, address, email, phone number, etc.).
  3. Enter the promo code if necessary during registration for the welcome offer.
  4. Meet the minimum deposit requirement (usually $5 or $10).
  5. Place your bets on any NFL preseason game.
  6. Once your bet settles, you can usually earn bonus bets depending on your chosen welcome offer.
  7. Use your bonus bets on the sportsbook, and remember they usually expire within 7 days of receiving them.

Best Bets for NFL Preseason Week 1

Here are some of our favorite picks for the weekend NFL preseason games, with odds from different sportsbooks.

  • Patriots -6.5 vs. Commanders (-110 at FanDuel): Look for new coach Mike Vrabel to make a statement in his return to New England with a rebuilt Patriots team.
  • Vikings -1.5 vs. Texans (-110 at BetMGM): With J.J. McCarthy back at quarterback for the Vikings, he’ll put on a show in front of the home crowd, and the Vikings should win this one as a deeper roster than Houston.
  • Steelers-Jaguars Under 35.5 Points (-105 at FanDuel): With Mike Tomlin not wanting to show much of his new-look offense with Aaron Rodgers, and rookie coach Liam Coen likely feeling the same way with the Travis Hunter experiment, the under is the best bet here.
  • Broncos -6 vs. 49ers (-110 at Bet365): Sean Payton takes the preseason seriously, and the Broncos are one of the strongest favorites this week against a San Francisco team that needs to keep everyone healthy.
  • Chicago Bears Over 16.5 Points vs. Dolphins (-130 at Bet365): Look for new coach Ben Johnson to make a difference in Week 1 with his offense scoring at least 17 points against a Miami defense that isn’t deep at all.

Washington Commanders vs. New England Patriots Week 1 NFL Preseason game line at FanDuel

Best Sportsbook to Use for NFL Preseason Betting

Here are some of the highest-rated online NFL sportsbooks to do your preseason betting on for Week 1:

Sportsbook Bonus Offer Best for Link
1. FanDuel Bet $5, get $150 if first bet wins User Interface Sign Up »
2. DraftKings Bet $5, get $200 + $200 Off NFL Sunday Ticket NFL Welcome Offer Sign Up »
3. Bet365 Bet $5, get $150 or $1,000 safety net Competitive Odds Sign Up »
4. BetMGM $1,500 back if first bet loses Football Props Sign Up »
5. Caesars Double winnings on next 10 bets + $250 bet match 2x Winnings Promo Sign Up »
6. Hard Rock Bet Bet $5, get $150 instantly Mobile App Experience Sign Up »
7. Fanatics $100 back if first bet loses (10x) $1,000 Bonus Sign Up »
8. ESPN BET Bet $10, get $100 & ESPN+ ESPN Brand Integration Sign Up »

How to Watch Every NFL Week 1 Preseason Game

If you’re curious how to watch NFL preseason action, you can catch some of the games like Browns vs. Panthers, Giants vs. Bills, Texans vs. Vikings, Jets vs. Packers, and both Sunday games (Dolphins vs. Bears, Saints vs. Chargers) live on NFL Network.

Otherwise, you’ll need to look at local broadcast options for regional coverage on your local CBS, FOX, NBC, or team-related affiliates.

There are also streaming options like FuboTV and Sling TV. If you have an NFL+ subscription, you can stream live games that are not in your local market on a variety of devices.

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