Another Sunday, another round of significant injuries across the NFL.

As teams begin to game plan for Week 7, several will be doing so without key contributors.

From high-ankle sprains to potential season enders, here is a comprehensive look at the most impactful injuries from the past week of action and the initial timelines for their return.

Be sure to bookmark our NFL Injured Reserve Tracker, which will be updated weekly throughout the season.

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Biggest NFL Week 6 Injuries:

Fred Warner Injury Update

49ers LB Fred Warner was carted off the field in an aircast on Sunday after suffering an ankle injury against the Buccaneers.

Warner has already been ruled out for the season with a broken and dislocated ankle.

The San Francisco defense has already lost Nick Bosa for the season to a torn ACL, and the offense has been missing Brock Purdy, George Kittle, Ricky Pearsall, and Brandon Aiyuk at various times this year.

Marvin Harrison Jr. Injury Update

Cardinals WR Marvin Harrison Jr. was sent to the locker room in the first half after his head slammed into the turf on a catch over the middle.

After a brief stint in the medical tent, Harrison was moved inside to be tested for a concussion.

He did not return to the game.

With Harrison out, Zay Jones caught 5 passes for 79 yards, and Michael Wilson hauled in 4 for 44 yards.

Puka Nacua Injury Update

Rams WR Puka Nacua was injured on a jump ball on Sunday and had to be helped off the field after he was limping around the end zone.

Nacua returned in the second half, but after the game, coach Sean McVay said he was not sure if Nacua would be ready for Week 7.

The Rams have a bye in Week 8, and they tend to be cautious with injuries.

This is certainly one to watch.

Emeka Egbuka Injury Update

Buccaneers WR Emeka Egbuka was ruled out of Sunday's win due to a hamstring injury.

The rookie wasn't the only Tampa wide receiver on the sideline with Mike Evans and Chris Godwin absent with their own leg injuries.

Todd Bowles did not have much of an update following the game, saying the team was still evaluating Egbuka's condition.

Garrett Wilson Injury Update

WR Garrett Wilson suffered an injury during Sunday morning's game in London.

Wilson had just three catches for 13 yards in the loss and only spent a short time in the medical tent.

There have been reports that Wilson is dealing with a knee injury, but head coach Aaron Glenn told the media it was a hip issue.

Wilson will have further tests.

Trey Hendrickson Injury Update

Bengals EDGE Trey Hendrickson suffered a back injury against the Packers, and he was ruled out in the second half.

Hendrickson leads the team with 4 sacks and 12 pressures.

Cincy's already struggling defense cannot afford to be without Hendrickson for any amount of time.

Kyler Murray Injury Update

Cardinals QB Kyler Murray was ruled out for Week 6 because of a foot injury.

Jacoby Brissett started in his place.

Murray was able to get in a limited practice on Friday, but ESPN's Adam Schefter reported that Brissett took all the first-team snaps, suggesting the Cardinals never expected Murray to play.

With a bye in Week 8, the Cardinals could opt to hold Murray out again next week to allow him to get back to 100%.

Calvin Ridley Injury Update

Titans WR Calvin Ridley exited Week 6 early with a hamstring injury.

After the game, coach Brian Callahan said the receiver couldn't run after suffering the injury.

It would not be surprising if Ridley ends up on injured reserve.

Other Notable Week 6 Injuries

  • Baltimore's injury woes continued in Week 6. They lost LT Ronnie Stanley to an ankle injury, and EDGE Tavius Robinson suffered a broken foot.
  • Eagles DL Jalen Carter sat out Thursday night against the Giants with a heel injury, though NFL Network's Ian Rapoport reported the decision to sit Carter was influenced by the infamous MetLife turf.
  • The Eagles also lost CB Quinyon Mitchell on Thursday night to a hamstring injury.
  • Colts QB Anthony Richardson suffered an orbital fracture while warming up before Indy's Week 6 game. The backup is likely to miss several weeks.
  • The Colts also lost CB Charvarius Ward in pregame warmups. He suffered a concussion when he ran into a teammate.
  • Rams backup RB Blake Corum exited with an ankle injury in the first half.
  • Cardinals RB Emari Demercado left Week 6 with an ankle injury.
  • Browns TE David Njoku exited Week 6 early with a knee injury. He seemed to play through the issue for part of the game, but he ultimately went to the locker room in the fourth quarter.
  • Cleveland also lost RT Jack Conklin to a concussion and LT Cam Robinson to a knee injury.
  • Packers EDGE Lukas Van Ness left Week 6 with a foot injury. The team does not believe he suffered any broken bones, but he will get an MRI on Monday.
  • Steelers CB Darius Slay suffered a shoulder injury on Sunday.