Use our free tool to find college football odds for the top games every week of the 2026 season.
Spreads, totals, and moneylines for the top college football games, plus expert picks from Ryan McCrystal.
Additional Betting Tools:
| Matchup | Kickoff (Eastern) | Point Spread (home team) | Total Points (over/under) | Moneyline (away / home) |
|---|---|---|---|---|
| Northwestern Wildcats at No. 5 Indiana Hoosiers | Friday, September 25, 8:00 p.m. ET | -21 | 49.5 | +1050 / -1800 |
| No. 1 Texas Longhorns at No. 14 Tennessee Volunteers | Saturday, September 26, 12:00 p.m. ET | +5.5 | 55.5 | -220 / +180 |
| Illinois Fighting Illini at No. 7 Ohio State Buckeyes | Saturday, September 26, 12:00 p.m. ET | -27.5 | 53.5 | +1600 / -4000 |
| Sam Houston Bearkats at No. 11 Texas Tech Red Raiders | Saturday, September 26, 12:00 p.m. ET | -34.5 | 54.5 | +3500 / -20000 |
| Wake Forest Demon Deacons at No. 16 Louisville Cardinals | Saturday, September 26, 12:00 p.m. ET | -12.5 | 58.5 | +380 / -500 |
| No. 3 Notre Dame Fighting Irish at Purdue Boilermakers | Saturday, September 26, 2:00 p.m. ET | +27.5 | 57.5 | -4000 / +1600 |
| Oklahoma Sooners at No. 2 Georgia Bulldogs | Saturday, September 26, 3:30 p.m. ET | -13.5 | 43.5 | +425 / -575 |
| No. 4 Ole Miss Rebels at No. 21 Florida Gators | Saturday, September 26, 3:30 p.m. ET | -3.5 | 60.5 | +130 / -160 |
| No. 15 Utah Utes at Iowa State Cyclones | Saturday, September 26, 3:30 p.m. ET | +7.5 | 48.5 | -350 / +270 |
| No. 17 Iowa Hawkeyes at No. 18 Michigan Wolverines | Saturday, September 26, 3:30 p.m. ET | -5.5 | 37.5 | +180 / -210 |
| No. 25 Houston Cougars at Georgia Southern Eagles | Saturday, September 26, 4:00 p.m. ET | +18.5 | 56.5 | -1100 / +700 |
| Vanderbilt Commodores at Auburn Tigers | Saturday, September 26, 4:15 p.m. ET | -9.5 | 55.5 | +275 / -350 |
| Wisconsin Badgers at No. 13 Penn State Nittany Lions | Saturday, September 26, 5:00 p.m. ET | -9.5 | 44.5 | +290 / -360 |
| Nebraska Cornhuskers at Michigan State Spartans | Saturday, September 26, 5:00 p.m. ET | +5.5 | 48.5 | -220 / +180 |
| Central Michigan Chippewas at No. 6 Miami Hurricanes | Saturday, September 26, 6:30 p.m. ET | -41.5 | 53.5 | — / — |
| South Carolina Gamecocks at No. 8 Alabama Crimson Tide | Saturday, September 26, 7:00 p.m. ET | -11.5 | 54.5 | +380 / -500 |
| No. 23 Texas A&M Aggies at No. 10 LSU Tigers | Saturday, September 26, 7:30 p.m. ET | -8.5 | 52.5 | +270 / -340 |
| No. 20 Oregon Ducks at No. 12 USC Trojans | Saturday, September 26, 7:30 p.m. ET | +3 | 62.5 | -155 / +130 |
| No. 19 Missouri Tigers at No. 24 Mississippi State Bulldogs | Saturday, September 26, 7:45 p.m. ET | -6 | 58.5 | +190 / -235 |
| Missouri State Bears at No. 22 SMU Mustangs | Saturday, September 26, 9:00 p.m. ET | -34.5 | 59.5 | +3500 / -9000 |
Ryan McCrystal's College Football Picks: Week 4 Best Bets
Coming Soon!
Finding the Best Number
Margins in sports betting are razor-thin, so finding the best number matters.
That is especially true in college football, where key numbers are a little less important than in the NFL.
Betting volume is also lower, which means the numbers aren't quite as sharp.
That is especially true when looking at smaller schools and conferences.
All of that leads to bigger differences between lines at the top sportsbooks in college football, which makes shopping for the best line even more important.
Use our College Football Odds tool at the top of this page to find the best game lines, totals, and moneylines for the top college football games every week.
