Use our free tool to find NFL odds every week of the 2026 season.
Spreads, totals, and moneylines for every NFL game, plus expert picks from Josh Shepardson.
Additional Betting Tools:
Week 6 NFL Betting Odds
| Matchup | Kickoff (Eastern) | Point Spread (home team) | Total Points (over/under) | Moneyline (away / home) |
|---|---|---|---|---|
| Buffalo Bills at Los Angeles Rams | Monday, October 12, 8:15 p.m. ET (week 5) | -3.5 | 55.5 | +145 / -175 |
| Seattle Seahawks at Denver Broncos | Thursday, October 15, 8:15 p.m. ET | +3 | 41 | -155 / +130 |
| Houston Texans at Jacksonville Jaguars | Sunday, October 18, 9:30 a.m. ET | -2.5 | 42.5 | +120 / -145 |
| Chicago Bears at Atlanta Falcons | Sunday, October 18, 1:00 p.m. ET | +3 | 49.5 | -175 / +145 |
| Baltimore Ravens at Cleveland Browns | Sunday, October 18, 1:00 p.m. ET | +4.5 | 41.5 | -235 / +190 |
| Carolina Panthers at Philadelphia Eagles | Sunday, October 18, 1:00 p.m. ET | -1 | 41.5 | -105 / -115 |
| Tennessee Titans at Indianapolis Colts | Sunday, October 18, 1:00 p.m. ET | -7 | 44 | +260 / -325 |
| New York Jets at New England Patriots | Sunday, October 18, 1:00 p.m. ET | -7.5 | 43.5 | +280 / -355 |
| New Orleans Saints at New York Giants | Sunday, October 18, 1:00 p.m. ET | -1.5 | 45.5 | -110 / -110 |
| Pittsburgh Steelers at Tampa Bay Buccaneers | Sunday, October 18, 1:00 p.m. ET | +3 | 40.5 | -150 / +125 |
| Los Angeles Chargers at Kansas City Chiefs | Sunday, October 18, 4:25 p.m. ET | -8.5 | 42.5 | +340 / -440 |
| Dallas Cowboys at Green Bay Packers | Sunday, October 18, 8:20 p.m. ET | -1 | 52.5 | -105 / -115 |
| Washington Commanders at San Francisco 49ers | Monday, October 19, 8:15 p.m. ET | -7.5 | 50.5 | +320 / -425 |
Josh Shepardson's NFL Picks: Week 6 Best Bets
Coming Soon!
Joe Gibbs' Referee Analysis & Week 6 Betting Impact
Coming Soon!
| Sharp NFL Betting Picks |
|---|
| Best Bets: ATS & Game Total Picks (Thursday) |
| Player Props & Predictions (Friday) |
| Referee Assignments & Penalty Trends (Thursday) |
| Key NFL Injuries: Betting Impact & Picks (Saturday) |
| Passing Yards Leader Odds (Friday) |
| Receiving Yards Leader Odds (Friday) |
| Rushing Yards Leader Odds (Friday) |
| First & Anytime Touchdown Picks |
| Parlay Picks & Same Game Parlays |
| Weather Betting Impact |
| Odds & Picks |
| Prop Odds & Picks |
| Implied Totals |
| Matchups Tool |
| Fantasy Cheat Sheet |
Finding the Best Number
Margins in sports betting are razor-thin, so finding the best number matters.
That is especially true in the NFL, where key numbers matter more than in any other sport.
Around 15% of NFL games end in a 3-point margin, which means the difference between -2.5 or -3.5 and -3 is massive.
Unsurprisingly, 7 is the second-most important key number, though the new extra-point rule has adjusted things a bit.
In addition to more missed extra points, teams are going for two more often after touchdowns.
From 2015 to 2025, teams went for two after 9% of touchdowns league-wide.
The ten years before that, the rate was 4.4%.
As a result, 6-point, 8-point, and even 5-point margins have become more prominent.
Use our NFL Odds tool at the top of this page to find the best game lines, totals, and moneylines for every NFL game this season.
NFL Point Spread Key Numbers
- 3 points
- 7 points
- 10 points
- 6 points
- 8 points
