Use our free tool to find college football odds for the top games every week of the 2026 season.
Spreads, totals, and moneylines for the top college football games, plus expert picks from Ryan McCrystal.
Additional Betting Tools:
| Matchup | Kickoff (Eastern) | Point Spread (home team) | Total Points (over/under) | Moneyline (away / home) |
|---|---|---|---|---|
| No. 4 Ohio State Buckeyes at No. 5 Indiana Hoosiers | Saturday, October 17, 12:00 p.m. ET | +3.5 | 50.5 | -170 / +142 |
| Florida Gators at No. 7 Texas Longhorns | Saturday, October 17, 12:00 p.m. ET | -10.5 | 52.5 | +325 / -425 |
| No. 16 Mississippi State Bulldogs at No. 22 LSU Tigers | Saturday, October 17, 12:00 p.m. ET | -14 | 58.5 | +400 / -550 |
| Virginia Cavaliers at No. 24 SMU Mustangs | Saturday, October 17, 12:00 p.m. ET | -8.5 | 51.5 | +260 / -325 |
| No. 25 Northwestern Wildcats at Michigan State Spartans | Saturday, October 17, 12:00 p.m. ET | +7.5 | 48.5 | -315 / +250 |
| Pittsburgh Panthers at Boston College Eagles | Saturday, October 17, 12:00 p.m. ET | +6.5 | 43.5 | -225 / +185 |
| Auburn Tigers at No. 1 Georgia Bulldogs | Saturday, October 17, 3:30 p.m. ET | -20.5 | 49.5 | +850 / -1450 |
| No. 6 Alabama Crimson Tide at No. 14 Tennessee Volunteers | Saturday, October 17, 3:30 p.m. ET | +8.5 | 51.5 | -325 / +260 |
| No. 13 Missouri Tigers at No. 9 Ole Miss Rebels | Saturday, October 17, 3:30 p.m. ET | -6 | 59.5 | +180 / -220 |
| Arizona State Sun Devils at No. 10 Texas Tech Red Raiders | Saturday, October 17, 3:30 p.m. ET | -14.5 | 48.5 | +500 / -700 |
| Penn State Nittany Lions at Michigan Wolverines | Saturday, October 17, 3:30 p.m. ET | -6.5 | 42.5 | +200 / -245 |
| Florida State Seminoles at No. 3 Miami Hurricanes | Saturday, October 17, 7:00 p.m. ET | -21 | 55.5 | +1000 / -2000 |
| No. 2 Notre Dame Fighting Irish at No. 8 BYU Cougars | Saturday, October 17, 7:30 p.m. ET | +10 | 47.5 | -400 / +310 |
| Wisconsin Badgers at No. 12 UCLA Bruins | Saturday, October 17, 7:30 p.m. ET | -2.5 | 44.5 | +110 / -135 |
| No. 15 Kentucky Wildcats at Oklahoma Sooners | Saturday, October 17, 7:30 p.m. ET | -7 | 43.5 | +210 / -260 |
| No. 18 Oklahoma State Cowboys at No. 20 Houston Cougars | Saturday, October 17, 7:30 p.m. ET | -4.5 | 61.5 | +160 / -190 |
| Louisville Cardinals at Syracuse Orange | Saturday, October 17, 7:30 p.m. ET | +14.5 | 56.5 | -700 / +500 |
| No. 11 Utah Utes at Colorado Buffaloes | Saturday, October 17, 10:15 p.m. ET | +15.5 | 49.5 | -800 / +550 |
| No. 21 Wake Forest Demon Deacons at California Golden Bears | Saturday, October 17, 10:30 p.m. ET | +9.5 | 53.5 | -360 / +285 |
| Nebraska Cornhuskers at Oregon Ducks | Saturday, October 17, 11:00 p.m. ET | -7.5 | 52.5 | +240 / -295 |
Ryan McCrystal's College Football Picks: Week 7 Best Bets
- Indiana +3.5 points
- Alabama -7.5 points
Ohio State vs. Indiana Game Breakdown
Ohio State's offense is led by first-year coordinator Arthur Smith, though the scheme closely resembles the offense used by the Buckeyes throughout Ryan Day‘s tenure.
According to FourthAndShort, Ohio State throws the ball at a rate 3.0% above expected based on situational data, and most of the passing attack flows through Jeremiah Smith.
In the first half of games, Smith has commanded a 38% target share while accounting for 50% of the Buckeyes' receiving yards.
Smith has also accounted for 51% of Ohio State's targets at 10 or more yards downfield in the first half.
When one receiver dominates the workload to such an extreme degree, it often signals a lack of depth, but the explanation might be more simplistic for Ohio State.
Despite being widely regarded as one of the greatest receivers in college football history, Smith has never been a Heisman finalist or even won the Biletnikoff Award.
Smith has talked openly about wanting to get to New York for the Heisman ceremony this season, and the Buckeyes appear to be making an effort to make that happen.
When Ohio State does not target Smith, the offense has been just fine.
On throws 10 or more yards downfield directed at receivers other than Smith, Ohio State is completing 59% of its passes, which would rank eighth in the FBS per Sports Info Solutions.
So there's good reason to believe Ohio State can be effective even if Indiana limits Smith's production, though receivers Brandon Innis and Devin McCuin both sat out last week's game against Maryland.
It's unclear why they were held out, though both players are off the injury report this week.
It's also worth noting Indiana does not have the same level of talent in the secondary as last year when D'Angelo Ponds matched up against Smith.
Take a look at how Indiana's starting outside cornerbacks Jamari Sharpe and Jaylen Bell have fared against power-conference competition compared to Sharpe and Ponds in 2025:
Outside CBs Yds/Att Ball-Hawk Rate TD-INT PI Penalties 2025 Ponds/Sharpe 6.5 20% 1-2 1 2026 Sharpe/Bell 8.8 18% 1-1 2
Fortunately for Sharpe and Bell, the pass-rush unit might be able to help them out.
Check out the pass-protection battle based on these opponent-adjusted numbers from Sports Info Solutions:
- Ohio State: ranked 84th in pressure rate allowed
- Indiana: ranked 4th in pressure rate generated
Ohio State's inability to protect Julian Sayin was a critical factor in last year's matchup.
He faced pressure on 44% of his dropbacks, the second-highest rate he faced all year.
Click here for Ryan's full game analysis of Ohio State vs. Indiana
Alabama vs. Tennessee Game Breakdown
Alabama typically runs a pass-heavy offense under head coach Kalen DeBoer and his longtime coordinator Ryan Grubb, though this year's squad has been more balanced than DeBoer's first two seasons in Tuscaloosa.
For Tennessee to have a chance in this game, the Vols defense will need to solve DeBoer's offense, something it failed to do last year when the Tide put 37 points on the board.
In his first year on the job, Tennessee coordinator Jim Knowles appears to have turned around a Vols defense so far.
The Vols ranked 91st in scoring defense a season ago.
They rank 19th entering this contest.
However, Tennessee has yet to play a dangerous offense, especially one that attacks downfield with the volume and success of Alabama.
Outside the red zone, Alabama throws 15 or more yards downfield 33% of the time and has completed 60% of those passes (ranked 9th), per Sports Info Solutions.
Tennessee's downfield pass defense has been untested so far, facing downfield throws just 12% of the time, which appears to be more a reflection of the offenses the Vols have faced than a respect for their defense.
When teams have attacked the Vols secondary, they have found success.
Even Arch Manning, who struggles as a downfield passer, was 5 for 7 on throws of 15 or more yards against Tennessee.
He's 14 for 30 at that depth against everyone else.
However, in order to attack downfield, Alabama will need to be able to protect Keelon Russell, which won't necessarily be easy.
Check out the pass-protection battle based on these opponent-adjusted numbers from Sports Info Solutions:
- Alabama: ranked 79th in pressure rate allowed
- Tennessee: ranked 10th in pressure rate generated
A strong pass rush is potentially how Tennessee can disrupt the Alabama passing attack because it does not look like the Tide can adjust their strategy effectively based on what we've seen against the best defenses they have faced.
Click here for Ryan's full game analysis of Alabama vs. Tennessee
Finding the Best Number
Margins in sports betting are razor-thin, so finding the best number matters.
That is especially true in college football, where key numbers are a little less important than in the NFL.
Betting volume is also lower, which means the numbers aren't quite as sharp.
That is especially true when looking at smaller schools and conferences.
All of that leads to bigger differences between lines at the top sportsbooks in college football, which makes shopping for the best line even more important.
Use our College Football Odds tool at the top of this page to find the best game lines, totals, and moneylines for the top college football games every week.
